Blueprint Playbook for Guardant Health

Who the Hell is Jordan Crawford?

Founder of Blueprint. I help companies stop sending emails nobody wants to read.

The problem with outbound isn't the message. It's the list. When you know WHO to target and WHY they need you right now, the message writes itself.

I built this system using government databases, public records, and 25 million job posts to find pain signals most companies miss. Predictable Revenue is dead. Data-driven intelligence is what works now.

The Old Way (What Everyone Does)

Your GTM team is buying lists from ZoomInfo, adding "personalization" like mentioning a LinkedIn post, then blasting generic messages about features. Here's what it actually looks like:

The Typical Guardant Health SDR Email:

Subject: Precision oncology insights for [Hospital Name] Hi [Name], I saw on LinkedIn that your team is expanding your cancer care program—congrats on the growth! At Guardant Health, we're transforming how oncologists make treatment decisions with our liquid biopsy platform. We provide comprehensive genomic profiling from a simple blood draw, helping physicians identify targeted therapies faster. Our clients report better patient outcomes and streamlined workflows. Would you have 15 minutes next week to discuss how we could support your precision medicine initiatives? Best, [SDR Name]

Why this fails: The prospect is an expert. They've seen this template 1,000 times. There's zero indication you understand their specific situation. Delete.

The New Way: Intelligence-Driven GTM

Blueprint flips the approach. Instead of interrupting prospects with pitches, you deliver insights so valuable they'd pay consulting fees to receive them.

1. Hard Data Over Soft Signals

Stop: "I see you're hiring compliance people" (job postings - everyone sees this)

Start: "Your ACO's colorectal cancer mortality rate is 18% above the CMS benchmark" (Medicare Shared Savings Program data with specific performance metrics)

2. Mirror Situations, Don't Pitch Solutions

PQS (Pain-Qualified Segment): Reflect their exact situation with such specificity they think "how did you know?" Use government data with dates, record numbers, facility addresses.

PVP (Permissionless Value Proposition): Deliver immediate value they can use today - analysis already done, deadlines already pulled, patterns already identified - whether they buy or not.

Guardant Health PQS Plays: Mirroring Exact Situations

These messages demonstrate such precise understanding of the prospect's current situation that they feel genuinely seen. Every claim traces to a specific government database with verifiable record numbers.

PQS Public Data Strong (8.4/10)

Your County Screening Rate: 58%

What's the play?

Target CoC-accredited cancer centers in counties with colorectal screening rates 9+ points below state average. These facilities see high volumes of late-stage colorectal cases because their population isn't getting screened.

Why this works

You're presenting specific county-level data the prospect can verify instantly via PLACES dataset. The 9-point gap and annual case volume prove you researched their facility specifically. The routing question is easy to answer and acknowledges they may already have a strategy in place.

Data Sources
  1. CDC PLACES - colorectal_cancer_screening_rate, county, zip_code_tabulation_area
  2. Commission on Cancer Hospital Locator - facility_name, location, cancer_services_offered

The message:

Subject: Your county's colorectal screening rate: 58% Davidson County's colorectal cancer screening rate is 58% - 9 points below the Tennessee average. Your facility treats 340 colorectal cases annually, but most present at Stage III-IV. Who owns your screening outreach strategy?
PQS Public Data Strong (8.1/10)

Your ACO Cancer Mortality 18% Above Benchmark

What's the play?

Target ACO-participating hospital systems where cancer mortality rates trail peer benchmarks despite shared savings participation. These systems face financial penalties for underperformance on quality metrics.

Why this works

The mortality gap and financial impact ($340K) are concrete and verifiable in CMS reports. This ties directly to the CMO's compensation and budget responsibilities. The message is blunt about underperformance but it's factual, not accusatory.

Data Sources
  1. Medicare Shared Savings Program Data - aco_name, quality_metrics, performance_data
  2. National Cancer Database Public Benchmark Reports - facility_type, survival_outcomes, treatment_patterns

The message:

Subject: Your ACO cancer mortality 18% above benchmark Your ACO's colorectal cancer mortality rate is 18% above the CMS benchmark for your risk-adjusted cohort. That gap translates to $340K in shared savings at risk under your 2025 quality metrics. Who's leading your cancer care quality improvement?
PQS Public Data Strong (8.3/10)

CMS Flagged Your Colorectal Cancer Outcomes

What's the play?

Target ACOs where colorectal cancer survival rates are 12+ percentage points below peer benchmarks and colorectal accounts for 20%+ of cancer volume. This is their largest quality gap.

Why this works

Uses specific CMS data the prospect can verify. Identifies the cancer type and volume impact. The question assumes they might NOT be analyzing this, which is often true. Survival rate gaps tie directly to performance metrics.

Data Sources
  1. Medicare Shared Savings Program Data - aco_name, quality_metrics
  2. NCDB Public Benchmark Reports - survival_outcomes, stage_at_diagnosis, tumor_histology

The message:

Subject: CMS flagged your colorectal cancer outcomes CMS quality reports show your ACO's colorectal cancer 5-year survival rate is 12 percentage points below your peer benchmark. With colorectal accounting for 23% of your ACO's cancer volume, that's your largest quality gap. Is anyone analyzing your early detection rates?
PQS Public Data Strong (8.2/10)

58% Screening Rate in Your Service Area

What's the play?

Target cancer centers where primary service area screening rates are 9+ points below statewide average. Translate percentage gap into actual unscreened population count within facility radius.

Why this works

Geographic specificity shows real analysis. Translating percentage into actual unscreened population count (4,200 adults) makes it concrete. The question is about strategy, not accusatory. Directly relevant to cancer detection KPIs.

Data Sources
  1. CDC PLACES - colorectal_cancer_screening_rate, county, census_tract
  2. CoC Hospital Locator - facility_name, location

The message:

Subject: 58% screening rate in your service area Your primary service area has a 58% colorectal screening rate versus 67% statewide. That 9-point gap means roughly 4,200 unscreened adults age 45+ within 15 miles of your facility. Is your cancer center targeting that population?
PQS Public Data Strong (8.0/10)

Your Lung Cancer Outcomes Trail Peer ACOs

What's the play?

Target ACOs where lung cancer mortality rates are 20%+ above peer benchmark ACOs with similar demographics. Focus on systems where lung accounts for 30%+ of total cancer volume.

Why this works

Specific mortality gap with peer comparison. Volume percentage shows research depth. Focuses on treatment pathways, not just screening. Question is appropriately focused on process ownership.

Data Sources
  1. Medicare Shared Savings Program Data - aco_name, quality_metrics, beneficiary_count
  2. NCDB Public Benchmark Reports - facility_type, survival_outcomes, tumor_histology

The message:

Subject: Your lung cancer outcomes trail peer ACOs Your ACO's lung cancer mortality rate is 22% above peer benchmark ACOs with similar patient demographics. Lung accounts for 31% of your total cancer volume - your largest diagnostic category. Who's reviewing your lung cancer treatment pathways?
PQS Public Data Strong (8.1/10)

Polk County Screening Rate 14 Points Below State

What's the play?

Target rural CoC-accredited cancer centers in counties with screening rates 14+ points below state average where facility is only comprehensive cancer care provider within 40 miles.

Why this works

Specific county and gap data. Geographic context (only facility in 40 miles) shows market understanding. Primary care coordination question is strategic, not just operational. Screening is a known pain point in rural areas.

Data Sources
  1. CDC PLACES - colorectal_cancer_screening_rate, county
  2. CoC Hospital Locator - facility_name, location, cancer_services_offered

The message:

Subject: Polk County screening rate 14 points below state Polk County's colorectal screening rate is 53% - 14 points below the state average of 67%. Your CoC-accredited center is the only facility within 40 miles offering comprehensive cancer care. Is anyone coordinating with primary care on screening referrals?
PQS Public Data Strong (8.4/10)

Your Breast Cancer Screening Gap Costs $180K

What's the play?

Target ACOs where breast cancer screening rates are 11+ points below benchmark, impacting 800+ eligible women. Calculate financial impact on quality-based shared savings.

Why this works

Specific screening metric with financial translation. Patient volume (890 women) makes it concrete. Financial impact directly tied to compensation/budget. Clear accountability question.

Data Sources
  1. Medicare Shared Savings Program Data - aco_name, quality_metrics, beneficiary_count
  2. CDC PLACES - breast_cancer_screening_rate, county

The message:

Subject: Your breast cancer screening gap costs $180K Your ACO's breast cancer screening rate is 11 points below benchmark, impacting 890 eligible women. That gap is costing you an estimated $180K in quality-based shared savings under your 2025 contract. Who's accountable for closing the screening gap?
PQS Public Data Strong (8.2/10)

Your Region: 61% Screening vs 72% Statewide

What's the play?

Target cancer centers where primary service area screening rates are 11+ points below statewide average and facility sees 400+ new colorectal cases annually.

Why this works

Clear gap quantification. Annual case volume shows research. Connects screening to earlier detection (clinical goal). Leadership question is appropriately strategic.

Data Sources
  1. CDC PLACES - colorectal_cancer_screening_rate, county, census_tract
  2. CoC Hospital Locator - facility_name, location, cancer_services_offered

The message:

Subject: Your region: 61% screening vs 72% statewide Your primary service area's colorectal screening rate is 61% compared to 72% statewide - an 11-point gap. With your facility seeing 420 new colorectal cases annually, most could be caught earlier with better screening. Is your leadership prioritizing screening initiatives?
PQS Public Data Strong (8.3/10)

2025 ACO Quality Penalty Risk: Cancer Metrics

What's the play?

Target ACOs where cancer screening and outcomes metrics are tracking 15%+ below benchmark through Q3, putting them at risk for quality penalty instead of shared savings in 2025.

Why this works

Time-bound (Q3 2024, 2025 contract) shows current analysis. Financial swing ($520K) is attention-getting. Penalty vs savings framing is high-stakes. Forward-looking question about strategy.

Data Sources
  1. Medicare Shared Savings Program Data - aco_name, quality_metrics, performance_data

The message:

Subject: 2025 ACO quality penalty risk: cancer metrics Your ACO's cancer screening and outcomes metrics are tracking 15% below benchmark through Q3 2024. That puts you at risk for quality penalty instead of shared savings in 2025 - roughly $520K swing. Who's reviewing your cancer quality strategy for 2025?
PQS Public Data Strong (8.5/10)

Late-Stage Colorectal Cases at Your Facility

What's the play?

Target cancer centers where 68%+ of colorectal cases present at Stage III-IV versus 52% statewide average. This 16-point gap suggests screening infrastructure isn't reaching their patient population.

Why this works

Stage-specific data is exactly what CMOs track. Statewide comparison provides context. Connects late presentation to screening infrastructure. Partnership question is strategic and actionable.

Data Sources
  1. NCDB Public Benchmark Reports - stage_at_diagnosis, facility_type, tumor_histology
  2. CoC Hospital Locator - facility_name, location

The message:

Subject: Late-stage colorectal cases at your facility Your facility's colorectal cancer registry shows 68% of cases present at Stage III-IV versus 52% statewide. That 16-point gap suggests screening infrastructure isn't reaching your patient population effectively. Who owns your community screening partnerships?

Guardant Health PVP Plays: Delivering Immediate Value

These messages provide actionable intelligence before asking for anything. The prospect can use this value today whether they respond or not.

PVP Public Data Good (7.8/10)

Gap Analysis for Your ACO Cancer Metrics

What's the play?

Pull ACO's cancer quality metrics against CMS benchmarks and identify 3 specific screening/treatment gaps costing shared savings. Show which patient cohorts drive underperformance and estimated financial impact.

Why this works

Promises specific analysis they don't have. Ties directly to financial metrics (shared savings). Low-commitment ask to receive the analysis. Cohort-level specificity would be valuable.

Data Sources
  1. Medicare Shared Savings Program Data - aco_name, quality_metrics, performance_data
  2. NCDB Public Benchmark Reports - survival_outcomes, treatment_patterns, stage_at_diagnosis

The message:

Subject: Gap analysis for your ACO cancer metrics I pulled your ACO's cancer quality metrics against CMS benchmarks and identified 3 specific screening/treatment gaps costing you shared savings. The analysis shows which patient cohorts are driving your underperformance and the estimated financial impact. Want me to send the breakdown?
PVP Public Data Strong (8.6/10)

4,200 Unscreened Adults in Your Zip Codes

What's the play?

Map the 4,200 adults age 45+ in facility service area who are unscreened for colorectal cancer by ZIP code and insurance status. Show which ZIPs have highest concentration and which payers cover them.

Why this works

Specific actionable data (4,200 adults, by ZIP and insurance). Directly supports screening outreach planning. Easy yes/no question. Insurance status mapping is valuable for targeting. Could act on this immediately to plan outreach.

Data Sources
  1. CDC PLACES - colorectal_cancer_screening_rate, zip_code_tabulation_area, census_tract
  2. Census Bureau ACS Health Insurance Data - insurance_type, age_group, zip_code

The message:

Subject: 4,200 unscreened adults in your zip codes I mapped the 4,200 adults age 45+ in your service area who are unscreened for colorectal cancer by ZIP code and insurance status. The data shows which ZIPs have the highest concentration and which payers cover them. Want the ZIP-level breakdown?
PVP Public Data Good (7.7/10)

Colorectal Pathway Analysis for Your ACO

What's the play?

Analyze ACO's colorectal cancer patient flow from screening through treatment and identify where patients are falling through the cracks. Show 3 specific process gaps causing the 18% mortality benchmark miss.

Why this works

Process-focused, not just outcome-focused. Specific number of gaps identified. "Patient flow" analysis is exactly what CMOs need. Low-commitment ask. But lacks specificity about what the gaps actually are.

Data Sources
  1. Medicare Shared Savings Program Data - aco_name, quality_metrics
  2. NCDB Public Benchmark Reports - treatment_patterns, stage_at_diagnosis, survival_outcomes

The message:

Subject: Colorectal pathway analysis for your ACO I analyzed your ACO's colorectal cancer patient flow from screening through treatment and identified where patients are falling through the cracks. The data shows 3 specific process gaps causing your 18% mortality benchmark miss. Want the process map?
PVP Public Data Strong (8.5/10)

Screening Program Design for Davidson County

What's the play?

Build a screening program framework for Davidson County targeting the 4,200 unscreened adults in facility service area. Include ZIP-code targeting, payer mix, and estimated reach by outreach channel.

Why this works

Specific to their geography and population. "Framework" implies actionable structure. Includes practical implementation details (channels, payers). Could use this to build a business case internally. Very low barrier to say yes.

Data Sources
  1. CDC PLACES - colorectal_cancer_screening_rate, zip_code_tabulation_area
  2. Census Bureau ACS Health Insurance Data - insurance_type, zip_code

The message:

Subject: Screening program design for Davidson County I built a screening program framework for Davidson County targeting the 4,200 unscreened adults in your service area. It includes ZIP-code targeting, payer mix, and estimated reach by outreach channel. Want me to send the framework?
PVP Public Data Strong (8.7/10)

Your Top 5 ACO Cancer Quality Levers

What's the play?

Identify the 5 specific interventions that would close ACO's cancer quality gap fastest based on current benchmark position. Each includes patient cohort, estimated impact, and implementation complexity.

Why this works

Action-oriented (interventions, not just analysis). Prioritization is valuable - CMOs don't have time for everything. Implementation complexity shows practical thinking. Specific number (5 interventions) is concrete. Could present this to leadership.

Data Sources
  1. Medicare Shared Savings Program Data - aco_name, quality_metrics, performance_data
  2. NCDB Public Benchmark Reports - survival_outcomes, treatment_patterns, stage_at_diagnosis

The message:

Subject: Your top 5 ACO cancer quality levers I identified the 5 specific interventions that would close your ACO's cancer quality gap fastest based on your current benchmark position. Each one includes the patient cohort, estimated impact, and implementation complexity. Want the prioritized list?
PVP Public Data Good (7.4/10)

Patient Outreach List: 4,200 Unscreened Adults

What's the play?

Build a contact-ready list of 4,200 adults age 45+ in facility service area overdue for colorectal screening, segmented by ZIP and insurance. Include mailing addresses and insurance type for targeted outreach by payer.

Why this works

If real, this is extremely actionable. Insurance segmentation is valuable for targeted campaigns. But "contact-ready list" with mailing addresses might be overpromising unless addresses are truly available from public data. Feels a bit too good to be true - buyer may be skeptical.

Data Sources
  1. CDC PLACES - colorectal_cancer_screening_rate, zip_code_tabulation_area
  2. Census Bureau ACS Health Insurance Data - insurance_type, zip_code

The message:

Subject: Patient outreach list: 4,200 unscreened adults I built a contact-ready list of 4,200 adults age 45+ in your service area overdue for colorectal screening, segmented by ZIP and insurance. The list includes mailing addresses and insurance type so you can target outreach by payer. Want the list?

What Changes

Old way: Spray generic messages at job titles. Hope someone replies.

New way: Use public data to find companies in specific painful situations. Then mirror that situation back to them with evidence.

Why this works: When you lead with "Your ACO's colorectal cancer mortality rate is 18% above the CMS benchmark" instead of "I see you're hiring for oncology roles," you're not another sales email. You're the person who did the homework.

The messages above aren't templates. They're examples of what happens when you combine real data sources with specific situations. Your team can replicate this using the data recipes in each play.

Data Sources Reference

Every play traces back to verifiable public data. Here are the sources used in this playbook:

Source Key Fields Used For
CDC PLACES cancer_screening_prevalence, colorectal_cancer_screening_rate, breast_cancer_screening_rate, county, census_tract, zip_code_tabulation_area Low-Screening-Adherence Regions with CoC-Accredited Facilities
Commission on Cancer Hospital Locator facility_name, location, cancer_services_offered, accreditation_status, zip_code, distance_radius Low-Screening-Adherence Regions with CoC-Accredited Facilities
Medicare Shared Savings Program Data aco_name, aco_participants, beneficiary_count, performance_data, shared_savings_amount, quality_metrics, service_area ACO-Participating Systems with Below-Benchmark Cancer Outcomes
NCDB Public Benchmark Reports facility_type, treatment_patterns, survival_outcomes, stage_at_diagnosis, tumor_histology, surgical_resection_type, state_geography, patient_demographics ACO-Participating Systems with Below-Benchmark Cancer Outcomes
Census Bureau ACS Health Insurance Data insurance_type, age_group, zip_code Screening Program Design and Outreach Planning